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IISc Develops 3D-Printed Model to Study How Cancer Drugs Penetrate Tumours
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What Happened?
Researchers at IISc have created a low-cost 3D-printed device to study the effectiveness of cancer drugs in deeper tumor regions. This model simulates the nutrient-deprived conditions found in tumors.
Key points
- The device recreates conditions inside tumors, allowing study of drug response at different depths.
- It uses a 'Cells-in-Gel-in-Paper' model to simulate nutrient and oxygen levels.
- The researchers tested the model with MDA-MB-231 breast cancer cells.
- Results showed a decrease in live cells and an increase in dead cells deeper in the model.
- Doxorubicin penetration was less effective in deeper layers of the model.
- The study found antagonistic interactions between doxorubicin and paclitaxel when used together.
Key insights
- The model's design could facilitate more accessible drug screening methods.
- Understanding drug penetration may lead to improved treatment strategies for solid tumors.
- The findings may prompt further research into drug combinations for better efficacy.
Why it matters
This development could enhance the understanding of drug effectiveness in cancer treatment.
Tags
Entities
IISc· OrganizationMDA-MB-231· Cell Linedoxorubicin· Drugpaclitaxel· DrugBengaluru· City
Source
Times of India
